About the magical effect of retinoic acid

About the magical effect of retinoic acid

Retinoic acid, also known as Tretinoin or Vitamin A Acid, which is the metabolic intermediate of vitamin A in the body. It is yellow to orange powder. It smells like vitamin methylacetate. It is easily soluble in methanol, ethanol, acetone, chloroform and dichloromethane, as well as vegetable oil and fat. It is unstable when exposed to light and heat, absorbs moisture in the air, and deteriorates when aggregated with water.

Retinoic acid can affect the melanin production of melanocytes. Its role is multi-point. It can inhibit the activities of three types of catalytic enzymes such as tyrosine hydroxylase, dopa oxidase and dihydroxyindole oxidase, so as to reduce the formation of melanin and reduce skin pigmentation. Retinoic acid had no effect on tyrosinase activity and melanin composition of normal human melanocytes. When the skin is physiologically aged, or injured by drugs, ultraviolet radiation and trauma, retinoic acid can correct or prevent the abnormalities caused by harmful factors on the biochemical composition and morphological structure of dermal connective tissue, stimulate the synthesis of skin extracellular matrix protein, accelerate the formation of new connective tissue band in the upper part of dermis, and improve the tension strength of wound site. Retinoic acid had no effect on collagen synthesis in normal skin. In addition, retinoic acid has inhibitory activity on leukocyte chemotaxis, which plays an anti-inflammatory role.

First: Retinoic acid is suitable for acne vulgaris, especially blackhead acne skin lesions, senile, solar or drug-induced skin atrophy, ichthyosis and various abnormal keratinization and hyperpigmentation skin diseases, psoriasis.

Second: Retinoic acid can promote the renewal of epidermal cells, regulate the proliferation and differentiation of epidermal cells, make the stratum corneum cells loose and easy to fall off, help to remove acne, and inhibit the formation of new acne.

Third: Retinoic acid in retinoic acid can affect the production of melanin in melanocytes. Its effect is multi-site, and it has three types of catalytic enzymes such as tyrosine hydroxylase, dopa oxidase and dihydroxyindole oxidase. Activity has an inhibitory effect, thereby reducing melanin formation and reducing skin pigmentation.

Retinoic acid also affects the growth of bone and promotes the proliferation, differentiation and keratinolysis of epithelial cells. It is used to treat acne vulgaris, psoriasis, ichthyosis, lichen planus, pityriasis rubra, hair follicle keratosis, squamous cell carcinoma and melanoma.

Xi’an Lyphar Biotech Co., LTD was founded in 2011, we have rich experience in production and export Retinoic acid, purity is 98%min, If you want to know more details, feel free to contact us.

 

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